First you need to be precise why there is a need to tune the system.
If there is a performance issue then you need to check and identify whether it is for few transactions or for all or only during a certain time.
If the parameters are set as per the recommendations then what is the real problem?
If you are worried about the buffer swaps observed in Tx ST02 you may follow these SAP notes.
1918603 - High swaps in transaction ST02
625305 - Profile parameters for the error analysis buffer
649613 - Export/import buffer SWAPS
What matters is the hit ratio. I see most of them are above 98% except the Export/Import buffer.
In addition to these check whether the database parameters are set correctly and the server is rightly sized with CPU, memory, swap etc
Regards
RB